climatic droplet keratopathy and pterygium was examined in a group of Climatic droplet keratopathy was seen especially in aboriginal males who had worked. PDF | On Jan 1, , Khalid F Tabbara and others published Climatic Droplet Keratopathy. The band-shaped bilateral corneal opacities that sometimes develop in certain geographically defined parts of the world are characterized by the deposition of.

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No cases were found in individuals younger than 38 years old. Purchase access Subscribe to the journal. Although the eye depends on the energy from visible radiation to carry out its fundamental physiological processes, it can also be damaged by this radiation as well as by UVR. When we compared the prevalence of pterygium among the four regions there was no significant differencewhereas the prevalence of pinguecula was of significant difference.

Climatic droplet keratopathy CDK is a degenerative corneal disease of unknown etiology. In all regions, individuals manifest drinking yerba mate infusion a local infusion. CDK was only found in region 3 where individuals had partial deficiency of sAA and did not use eye protection.

Climatic droplet keratopathy: an old disease in new clothes.

The O 3 values determined during the last ten years in all the regions were within keraropathy normal range excluding the possibility of any thinning in the O 3 layer in any of these regions.

Create a free personal account to download free article PDFs, sign up for alerts, customize your interests, and more. Table 1 presents the data for the average age, gender distribution, and prevalence of CDK in individuals living in the four Argentinean regions.

Create a free personal account to make a comment, download free article PDFs, sign up for alerts and more. Sector iridectomy, corneal epithelial debridement, lamellar keratoplasty, and penetrating keratoplasty have all been employed in the treatment of visually incapacitating CDK.

Introduction InBaquis [ 1 ] described for the first time an acquired degenerative disease of the human cornea ddroplet degeneration of the corneapotentially disabling and being characterized by a slow progression to corneal opacity. Similar results were obtained when corneal epithelial cells were keratopatgy to UVR in vitro [ 4849 ]. Create a free personal account to make a comment, download free article PDFs, sign up for alerts and more.


Many years ago, the clinical and histological aspects of this disease were described in several kerstopathy.

Page Discussion View form View source History. However, getting these values requires the installation of equipment with constant evaluation by qualified staffs, which have to simultaneously record climatic factors, such as clouds and winds.

This page has been accessed 8, times. For each year, four measurements were obtained on March 21, June 21, September 21, and December droplte in order to determine the annual average. Enroll in the International Ophthalmologists contest.

Surprisingly, we did not find CDK in region 1 or 2 provinces of Jujuy and Santiago del Esterowhich had similar climate and soils and where individuals have similar eating habits and work activity to those of region 3. These values were lower than those determined for region 4 0.

Climatic droplet keratopathy.

Demographic data and prevalence of CDK in the four Argentinean regions. The first descriptions of the disease were given by Baquis in [ 1 ] and also in by Lugli [ 7 ]. Many individuals also received a test of visual acuity with a Snellen chart and Landolt rings or E for illiterate individuals, objective keratoppathy determination using an autorefractometer RK1, Canon Inc.

In summary we present new and convincing results that contribute to the increasing knowledge about the genesis of this human corneal degenerative disease which open the prospect for a new therapeutic strategy in the prevention as well as keratopsthy of CDK. The region experiences hot dry summers often exceptionally hot and cold winters, with great diurnal temperature variations.

BioMed Research International

InBaquis [ 1 ] described for the first time an acquired degenerative disease of the human cornea colloid degeneration of the corneapotentially disabling and being characterized by a slow progression to corneal opacity. Vegetables and fruit are exception items in the diet of the inhabitants of these regions. Values of pterygium and pinguecula are summarized in Table 2. Nonprobabilistic consecutive patients older than twenty years, who live during their entire life in any of these regions of Argentina and who agreed to take part in the study after reading a summary of the research project and signed a written consent, were examined by specialists in ophthalmology.

For these reasons, in the present investigation we did not calculate the UVR values at ground level for any of the four Argentinean regions. Although globular deposits in the anterior layer of the corneas with CDK were described many years ago using optical and electron microscopy [ 3637 ], more recently, these anomalies have been further characterized by us using in vivo confocal microscopy IVCM [ 38 ]. Only severe cases affecting vision need to be treated. Increasing age and exposure to ultraviolet light are the most common associated risk factors.

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It is protected from winds by the edges of the plateau, which act as walls. Sign in to driplet free article PDFs Sign in to access your subscriptions Sign in to your personal account.

The primary work activity is cattle breeding, with the exception being region 4, which has fruit collectors. Our results suggest that the enzymatic glycosylation may also be involved in the formation of deposits in CDK, since altered levels of N-glycosylation of certain proteins were observed in the tears of patients with CDK [ 47 ]. The authors declare that there is no conflict of interests regarding the publication of this paper.

The twenty-five CDK patients manifested they worked outdoors in sheep farming, never used eye protection, had a very restricted diet as previously shown during their life, and had the lowest AAs concentration. Indexed in Science Citation Index Expanded.

Create a personal account to register for email alerts with links to free full-text articles. Enroll in the Residents and Fellows contest. All classifications of spheroidal keratopathy are pathologically indistinguishable by both light and electron microscopy. Pinguecula prevalence was significantly higher than pterygium for regions 1, 2, and 3, but not for region 4. CDK was only found in high prevalence in individuals inhabiting one out of four Argentinean regions region 3: Also, in previous unpublished studies we have investigated the variation at the blood and HLA-DRB1 alleles groups between patients and relevant controls.

View at Google Scholar D. The results of the pinguecula and pterygium prevalence ophthalmoheliosis were as follows: Our website uses cookies to enhance your experience. All the individuals work outdoors during the greater part of the day. We have previously shown a lack of correlation between genetic ancestry as represented by haploid genetic systems and the incidence of CDK in Argentina [ 53 ].